Severe Hypoglycemia and Hyperglycemia from Diabetes Medications: Emergency Care Protocols

Severe Hypoglycemia and Hyperglycemia from Diabetes Medications: Emergency Care Protocols
Dec, 30 2025

Diabetes Emergency Decision Tool

Emergency Guidance Tool

Enter blood sugar value and ketone status to see emergency guidance

What Counts as a Diabetes Emergency?

When your blood sugar drops too low or spikes too high, it’s not just inconvenient-it’s life-threatening. Severe hypoglycemia happens when your blood glucose falls below 54 mg/dL and you can’t treat yourself. You might pass out, seize, or become unresponsive. On the flip side, severe hyperglycemia means your blood sugar climbs past 250 mg/dL with ketones in your blood or urine, signaling diabetic ketoacidosis (DKA), or above 600 mg/dL with extreme dehydration, pointing to hyperosmolar hyperglycemic state (HHS). These aren’t minor blips. They’re emergencies that demand immediate action.

Insulin is the most common culprit behind severe hypoglycemia. Too much insulin, missed meals, or intense exercise can send levels crashing. For hyperglycemia, it’s often missed insulin doses, illness, or new medications like SGLT2 inhibitors that trigger a dangerous rise. The CDC says about 37 million Americans have diabetes, and for those on insulin, the risk of severe hypoglycemia is as high as 30% every year. That’s not rare. It’s predictable-and preventable.

How to Treat Severe Hypoglycemia When You Can’t Help Yourself

If someone with diabetes is unconscious, confused, or seizing, don’t try to give them food or drink. You could choke them. Instead, give glucagon. It’s the only medication that can pull their blood sugar back up when they can’t swallow or respond.

There are three ways to give glucagon now-and they’re all better than the old way. The traditional glucagon kit requires mixing powder and liquid, then injecting it. Most people can’t do it under stress. That’s why new options exist:

  • Baqsimi: A nasal spray. Just insert it into one nostril and press the plunger. No needles. No mixing. Takes effect in 10-15 minutes.
  • Gvoke: A pre-filled autoinjector. Like an EpiPen. Press it against the thigh or arm and hold for 5 seconds.
  • Traditional glucagon injection: Still works, but only 42% of caregivers can use it correctly without training.

A 2021 study found that 83% of caregivers could successfully use nasal glucagon, compared to just 42% with the old kit. Time saved? From over two minutes down to 27 seconds. That matters when every second counts.

For mild low blood sugar (between 54 and 70 mg/dL), use the Rule of 15: eat exactly 15 grams of fast-acting carbs-like 4 glucose tablets, 4 oz of regular soda, or 1 tablespoon of honey. Wait 15 minutes. Check your blood sugar again. Repeat if needed. Don’t guess. Don’t eat a whole candy bar. Too much can cause a rebound high.

How to Handle Severe Hyperglycemia: DKA and HHS

Unlike hypoglycemia, you don’t treat severe hyperglycemia at home. You call 911 or go to the ER. The body is in crisis. It’s dehydrated, acidic, and starving for energy-even though blood sugar is sky-high.

Hospital treatment follows three steps:

  1. Fluids: You’ll get 1-2 liters of IV saline in the first hour to rehydrate and flush out ketones.
  2. Electrolytes: Potassium drops dangerously low during DKA. IV potassium is added to fluids to prevent heart rhythm problems.
  3. Insulin: Continuous IV insulin is given at 0.1 units per kg per hour. For mild DKA (pH >7.0), some doctors now use fast-acting insulin shots, but for severe cases, IV is still required.

Never give glucagon for high blood sugar. It will make it worse. Never give insulin without checking ketones. Giving insulin to someone with HHS without fluids can crash potassium levels and cause cardiac arrest.

Key warning signs of DKA: fruity breath, nausea, vomiting, abdominal pain, rapid breathing, confusion. For HHS: extreme thirst, dry skin, high fever, drowsiness, vision loss. If you see these, don’t wait. Go to the hospital.

Hospital emergency scene with glowing IV fluids and insulin tool, clock at 11:59, crimson rays.

Why Most People Are Unprepared

Here’s the hard truth: 63% of people with type 1 diabetes have had a severe low that required help. But only 41% always carry glucagon. Why? Fear. Most people are terrified of using it wrong.

One mom on Reddit shared how her child’s school nurse refused to give glucagon because she’d never been trained. The child had to wait for 911. That’s not an exception-it’s the norm.

Studies show only 28% of at-risk patients get proper glucagon training. And even when they do, most never practice. Without practice, skills fade. One study found that 92% of people who practiced glucagon administration quarterly kept the skill six months later. Those who didn’t? Only 45% remembered how.

Another problem? People wait too long to seek help for high blood sugar. A survey found 58% of DKA cases happened because patients waited over 12 hours after symptoms started. They thought it was just the flu. Or they didn’t know ketones were dangerous.

What Should Be in Your Emergency Kit

Every person on insulin-type 1 or type 2-needs an emergency kit. Not just a glucagon device. Here’s what to include:

  • Glucagon nasal spray (Baqsimi) or autoinjector (Gvoke)-check expiration dates every 3 months.
  • Glucose tablets (4g each)-pack at least four for mild lows.
  • Fast-acting carbs: small juice boxes, honey packets, or regular soda (not diet).
  • Blood ketone meter and test strips-check if blood sugar is over 250 mg/dL and you feel unwell.
  • Emergency contact list: your doctor, a family member, and your insulin pump or CGM manufacturer’s hotline.
  • A medical ID bracelet or card stating you have diabetes and are on insulin.

Store your kit where everyone can find it-your purse, car, desk, school locker. Don’t hide it in the back of a cabinet. If you’re traveling, carry two glucagon devices. One can expire. One can get lost.

Luxury medical emergency kit with glucagon devices, ketone meter, and medical ID on marble, Art Deco style.

Who’s at Highest Risk-and Why

It’s not just type 1 diabetes. People with type 2 on insulin are just as likely to have severe lows. But only 34% of them carry glucagon, compared to 68% of type 1 patients. That’s a gap in care.

Black and Hispanic patients are 2.3 times more likely to be hospitalized for severe hypoglycemia than white patients. Why? Lack of access. Medicaid patients face prior authorization for glucagon 31% of the time. Private insurance? Only 12%. That’s not a medical issue-it’s a systemic one.

Older adults are also at risk. They may not recognize symptoms. Or they’re on multiple medications that interact with insulin. And they’re less likely to have someone nearby who knows how to help.

What’s New in Emergency Care

The biggest breakthrough in recent years? The beta Bionics iLet-a dual-hormone artificial pancreas that automatically gives glucagon when it predicts a low. In trials, it cut severe hypoglycemia by 72%. But it’s only available at 12 U.S. centers right now.

Next up? Dasiglucagon, a new glucagon analog that works in under two minutes. It’s in phase 3 trials and could be approved by late 2024.

Also, new apps like Eli Lilly’s Gvoke HelperApp guide you through administration with video steps. If you get a new glucagon device, download the app. Practice with it. Even if you think you know how, you might be surprised.

What to Do Right Now

If you or someone you care for uses insulin:

  1. Ask your doctor for a prescription for Baqsimi or Gvoke-don’t settle for the old kit.
  2. Practice using the device with a trainer pen. Do it once a month.
  3. Teach at least two people how to use it-family, friend, coworker, school nurse.
  4. Keep glucagon in your bag, car, and workplace. Don’t rely on one location.
  5. Get a ketone meter. Test if your blood sugar is over 250 mg/dL and you feel sick.
  6. Wear a medical ID. It saves lives when you can’t speak.

Don’t wait for a crisis. Prepare now. Because when your blood sugar crashes or soars, there’s no time to read instructions. You need to act-and you need to know how.

15 Comments

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    srishti Jain

    January 1, 2026 AT 03:10
    This is why I keep glucagon in my purse, car, and damn near my sock drawer. One time my cousin passed out at a BBQ and I had to use it. No time to read instructions. Just press and pray.
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    Cheyenne Sims

    January 1, 2026 AT 17:28
    The clinical accuracy of this post is exemplary. Proper terminology, evidence-based thresholds, and adherence to ADA guidelines are non-negotiable in public health communication.
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    Shae Chapman

    January 3, 2026 AT 01:21
    I cried reading this. đŸ„ș My brother had a DKA episode last year and we didn’t know ketones were a red flag until he was in ICU. Please, please, please get a ketone meter. It’s not optional. I’m so glad this exists now.
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    Nadia Spira

    January 4, 2026 AT 14:38
    Let’s be real-this is just pharmaceutical marketing dressed as medical advice. Glucagon nasal spray? More like a $500 placebo for people too lazy to manage their insulin properly. The real issue is systemic neglect, not device accessibility.
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    henry mateo

    January 5, 2026 AT 02:57
    i just found out my mom has had type 2 for 15 years and never had a ketone meter... i feel so bad. gonna order her one today. thanks for the nudge. 🙏
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    Kunal Karakoti

    January 6, 2026 AT 16:59
    The body’s response to glucose extremes reveals a deeper truth: we are not machines, yet we treat diabetes as if we are. The real emergency isn’t the number-it’s the isolation, the fear, the lack of systemic support.
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    Glendon Cone

    January 8, 2026 AT 10:04
    I’m a nurse and I can’t tell you how many times I’ve seen families panic because they didn’t know glucagon wasn’t insulin. Baqsimi changed everything. My kid’s school now keeps one in the office. Game changer. 🙌
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    Henry Ward

    January 9, 2026 AT 15:23
    You people are so naive. Glucagon doesn’t fix the problem-it just patches the hole while the system keeps leaking. If you’re relying on a nasal spray to save your life, you’ve already lost.
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    Aayush Khandelwal

    January 11, 2026 AT 02:06
    The irony? We’ve got tech that can predict lows before they happen, but the system still treats patients like broken widgets. Glucagon’s not the hero-it’s the Band-Aid on a bullet wound. We need infrastructure, not gadgets.
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    Sandeep Mishra

    January 12, 2026 AT 14:22
    If you’re reading this and you’re scared to use glucagon-here’s what I tell my students: you won’t kill someone by giving it. But you might save them by trying. Practice with the trainer pen. Do it once a month. It’s not a skill-it’s a lifeline.
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    Joseph Corry

    January 13, 2026 AT 14:20
    The fact that you’re still discussing ‘glucagon kits’ in 2024 is a testament to the abysmal failure of medical education. This isn’t innovation-it’s damage control for a broken paradigm.
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    Hayley Ash

    January 14, 2026 AT 09:08
    So we’re supposed to believe that nasal glucagon is a miracle because it’s easier? What’s next-glucose gummies with a QR code that plays a lullaby?
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    kelly tracy

    January 14, 2026 AT 10:27
    This post is dangerously optimistic. People don’t die because they didn’t have glucagon. They die because they were never taught to prevent this in the first place. And now you’re selling us bandaids as solutions.
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    Kelly Gerrard

    January 15, 2026 AT 10:45
    I’ve been on insulin for 22 years. I carry two glucagon devices. I taught my dog. Just kidding. But seriously-get the kit. Wear the ID. Practice. Don’t wait for the emergency to learn how to live.
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    Colin L

    January 16, 2026 AT 03:15
    You know what’s worse than a severe low? The silence. The way people pretend it’s not happening. I’ve watched my uncle go through this three times. Once he was alone in his apartment for six hours before his neighbor heard him moaning. Six hours. And the worst part? He had glucagon. Just
 never opened the box. He was afraid he’d mess it up. So he waited. And waited. And waited. And now he’s gone. And I’m still here. And I still can’t believe we let this happen.

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